| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 | 28권 2호, p.381 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Controlled release of paclitaxel from microemulsion containing PLGA and evaluation of anti-tumor activity in vitro and in vivo |
| 초록 | The main objective this study was to develop a optimal paclitaxel microemulsion prepared by self-microemulsifying drug delivery system (SMEDDS) which is mixtures of drug, solubilizer, surfactant, and cosurfactant and paclitaxel microemulsion containing poly(D,L-lactide-co-glycolide) (PLGA) in order to offer controlled release of paclitaxel. The droplet size for all of the formulation of microemulsion was found in the range from 45 to 270 nm by dynamic light scattering (DLS). It was observed that the droplet size of microemulsion without PLGA was smaller than that of microemulsion containing PLGA by transmission electron microscopy (TEM) and droplet of microemulsion containing PLGA was almost the spherical shape with smooth surface and there was no aggregation or adhesion among droplet of microemulsion by atomic force microscopy (AFM). This result was identical with the result of anti-tumor activity in vitro of paclitaxel from microemulsion containing PLGA against human breast cancer cell line MCF7 and this formulation enhanced anti-tumor activity in vivo compared with microemulsion without PLGA against SKOV-3 human ovarian cancer cells bearing nude mice model. Acknowledgement: This work was supported by KMOCIE |
| 저자 | 강복기1, 전세강1, 이진수1, 길희주2, 정상영3, 강길선1, 김문석3, 이해방3, 조선행3 |
| 소속 | 1전북대, 2한남대, 3한국화학(연) |
| 키워드 | controlled release; self-microemulsifying drug delivery system; paclitaxel |
