| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Promoting bone regeneration by 3D-printed PGA/HAp composite scaffolds |
| 초록 |
Hydroxyapatite (HAp) is a major bone graft component for hard tissue regeneration. However, sintered HAp has poor formability and mechanical properties. Porous 3D scaffolds for bone tissue regeneration were printed with computer-aided modeling using poly(glycolic acid) (PGA) and HAp. PGA scaffolds containing HAp nanoparticles were fabricated with a 400 μm pore size. PGA/HAp scaffolds containing 12.5wt% HAp showed considerable compressive strength, osteogenesis, mineralization, and biodegradation. In in vivo animal experiments, the PGA/HAp group exhibited 47% bone regeneration, with superior bone mineral density 8 weeks after surgery. 3D-printed PGA/HAp scaffolds could provide a feasible option to promote patient-specific bone regeneration. |
| 저자 |
김현서1, 강동훈1, 고윤제1, 김은진2, 권오경3, 정호윤3, 권오형1
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| 소속 |
1금오공과대, 2테라시온바이오메디칼, 3경북대 |
| 키워드 |
Hydroxyapatite; 3D scaffold; PGA; bone regeneration
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| E-Mail |
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