A dental adhesive system was developed to yield a high bond strength to different substrates, enhanced durability, biocompatibility, and absence of interfacial microleakage. Such a system can be cured chemically (self-curing) or by visible light. Based on the assumption of an anaerobic character of the system＇s polymerization, the effect of the addition of an anaerobic accelerator (saccharin) on the curing mechanism was studied. Subsequently, the composition of the developed adhesive system and its curing conditions were evaluated and optimized. The developed adhesive compositions demonstrate high and durable bonding to dentin, enamel, porcelain, base and precious alloys, and amalgam, and can be used in different adhesive systems.