This paper considers the reduction of the adhesion of a flexible poly(urethane) layer cured onto a rigid solid substrate by the combined action of the variation of the surface topography of the latter and also by the application of externally applied mould release agents to the same. The influence of three interfacial variables is considered both singularly and in combination. These are the action of two proven release coating systems, their surface concentration, and the effects of the counterface topography. As an example, two effective release systems are chosen which are based upon a carboxylic ester wax suspension and a model multiphase (solid silicone combined with a fluid silicone)-based release system. These two systems are very effective in reducing the measured adhesion at poly(urethane)/steel interfaces and the influence of the counterface surface topography is considered. For the uncoated interfaces, increasing the counterface roughness results in a reduced adhesion. This effect is envisaged as being due to the relatively ineffective wetting of the curing poly(urethane) on the rougher substrates. With the coated interfaces, the combined effect of surface roughness, together with the release agent and its increased concentration, causes an apparent marked increase in the adhesion. This trend is considered to be probably due to a reduction in the effective roughness of the counterface and also a better wetting of the substrate. An optimum release agent surface concentration, on rough counterfaces, is observed for both release systems in order to provide the maximum adhesion. Usually, the adhesion increases with increasing release agent surface concentration for the rougher counterfaces.