A newly developed methodology for the design of multistream plate-fin heat exchangers in the optimization of heat exchanger networks is described in detail. The designed heat exchanger consists of several block sections with intermediate entry and exit points along its length, and these sections are determined by, the composite curves in the Pinch technology. The requirements of heat transfer and pressure drop are fulfilled through proper surface selection. The methodology was applied to an industrial case study, and the detailed design parameters are given. The example confirms the validity of the suggested methodology.