Co-combustion tests were performed in a 13.8 MWth industrial steam boiler, using Greek lignite from Ptolemais reserve, natural waste wood, MDF residues and power poles. Fuel blends were prepared by mixing single waste wood components with lignite in various concentrations. Oxygen concentration and emissions of CO, SO2 and NOx were continuously monitored, during the co-combustion tests. Gaseous and particulate samples were collected and analysed for heavy metals, dioxins and furans according to standard methods. The results showed that co-combustion is technically feasible provided that agglomeration problems could be confronted. Low emissions of toxic pollutants were obtained during the co-combustion tests, below the legislative limit values. The lowest values of dioxins and furans were observed during combustion of fuel blends containing MDF, possibly due to inhibition by some nitrogenous components in MDF. No direct correlation was found between emitted PCDD/F and metal compounds, especially copper. Among the measured metals in the flue gases, zinc was the most prominent, while iron was mainly observed in the solid ash samples.