In this paper, a generalized predictive observer-controller (GPOC) is developed for injection moulding with input delay and non-measurable states. First, based on a general state-space model with time delay and subject to process disturbances, a generalized predictive control (GPC) is appropriately formulated with a steady-state Kalman filter. Second, important and useful closed-loop characteristics relating to the stability and robustness of the proposed controller are provided. Finally, the proposed scheme is applied to the injection moulding to improve the control performance.