The aim of this work was to evaluate the possible synergy in hybrid catalysts composed of the two types of solids and to study their performances in the catalytic combustion of isopropanol. Several catalysts, based on cerium oxide and zeolites, for the catalytic oxidation of volatile organic compounds (VOCs), especially isopropanol, were tested. This study was assessed by determining the catalysts activity, selectivity and deactivation at various temperatures after 5 h of reaction. An important part of the work was the preparation and characterization of the catalysts, in particular the study of oxygen storage and mobility. Hybrid catalysts exhibit a synergy effect in terms of oxygen storage capacity and oxygen isotopic exchange. However, even if a synergy effect is also observed in catalytic oxidation over some samples, the oxygen mobility does not ensure better results in isopropanol combustion. (C) 2011 Elsevier B.V. All rights reserved.