Nanofluids are a suspension of particles with ultrafine size in a conventional base fluid that increases the heat transfer performance of the original base fluid. They show higher thermal performance than base fluids especially in terms of the thermal conductivity and heat transfer coefficient. During the last decade, many studies have been carried out on the heat transfer and flow characteristics of nanofluids, both experimentally and theoretically. The purpose of this article is to propose a dispersion model for predicting the heat transfer coefficient of nanofluids under laminar flow conditions. TiO2 nanoparticles dispersed in water with various volume fractions and flowing in a horizontal straight tube under constant wall heat flux were used. In addition, the predicted values were compared with the experimental data from He et al. [14]. In the present study, the results show that the proposed model can be used to predict the heat transfer behaviour of nanofluids with reasonable accuracy. Moreover, the results also indicate that the predicted values of the heat transfer coefficient obtained from the present model differ from those obtained by using the Li and Xuan equation by about 3.5% at a particle volume fraction of 2.0%. (C) 2012 Elsevier Ltd. All rights reserved.