CuS/PbS p-n heterojunction nanowires arrays have been successfully synthesized. Association of template and DC power sources by controllable electrochemistry processes offers a technique platform to efficiently grow a combined heterojunction nanowire arrays driven by a minimization of interfacial energy. The resulting p-n junction materials of CuS/PbS show highly uniform 1D wire architecture. The single CuS/PbS p-n heterojunction nanowire based devices were fabricated, and their electrical behaviors were investigated. The independent nanowires exhibited a very high ON/OFF ratio of 1195, due to the association effect of electrical switches and diodes.