Although the synthesis of silver nanoparticles via chemical precipitation is the easiest to scale up for industrial production, the use of conventional stirring methods suffers from large and widely distributed particle sizes due to poor macro- and micromixing efficiency which is vital in providing the necessary supersaturated conditions. These problems can be mitigated using the high-gravitational mixing method which significantly improves mixing efficiency and greatly reduces reaction times. In this work, we describe the preparation of silver nanoparticles from green materials using a high-gravitational rotating packed bed reactor and present our findings on the significance and effects of concentration and feed flow rate of reactants and packed bed rotation speed on the sample particle size and recovery yield. Taguchi statistical analysis was used to optimize each parameter for small particle size and high product yield. To determine the particle size and silver concentration of the synthesized samples, dynamic light scattering (DLS) and inductively coupled plasma mass spectrometry (ICP) were used respectively. X-ray diffraction (XRD), UV-vis spectroscopy, and transmission electron microscopy (TEM) imaging were used for further characterization of the produced nanoparticles.