The separation of paraffin isomers is a very important topic in the petrochemical industry. Zeolite SA is industrially used to sieve alkane isomers, but its pore size does not allow the separation of monobranched and dibranched alkanes by a kinetic mechanism. In this publication, we compare three ZIF materials in the separation of C6-paraffin isomers: ZIF-8, ZIF-76, and a new material called IM-22. The performance of the materials is evaluated by a breakthrough curve of binary mixtures of n-hexane, 3-methylpentane, and 2,2-dimethylbutane. We show that ZIF-8 is a very attractive alternative to zeolite SA because it exhibits a high (kinetic) selectivity for the adsorption of linear alkalies and at the same time a high adsorption capacity. The new material IM-22, a ZIF with CHA topology, seems to be particularly suited for the separation of mono- and dibranched paraffin isomers.