The removal of endocrine-disrupting compounds (EDCs) by lignin peroxidase from white-rot fungus Phanerochaete sordida YK-624 (YK-LiP1) was investigated. Five endocrine disruptors, p-t-octylphenol (OP), bisphenol A (BPA), estrone (E-1), 17 beta-estradiol (E-2), and ethinylestradiol (EE2) were eliminated by YK-LiP1 more effectively than lignin peroxidase from P. chrysosporium (Pc-LiP), and OP and BPA were disappeared almost completely in the reaction mixture containing YK-LiP1 after a 24-h treatment. Particularly, the removal of estrogenic activities of E-2 and EE2, which show much higher estrogenic activities than other EDCs such as BPA and OP, were removed following 24-h treatment with YK-LiP1. Moreover, 5,5'-bis(1,1, 3,3-tetramethylbutyl)-[1,1'-biphenyl]-2,2'-diol and 5,5'-bis[ 1-(4-hydroxy-phenyl)-1-methyl-ethyl]-biphenyl-2,2'-diol were identified as the main metabolite from OP or BPA, respectively. These results suggest that YK-LiP1 is highly effective in removing of EDCs by the oxidative polymerization of these compounds.