The kinetics of oxidation of mixtures of iso-octane with ethanol or 1-butanol (25/75%, 50/50%, and 75/25% in vol.) were studied experimentally using a fused silica jet stirred reactor. The experiments were performed in the temperature range 770-1190 K, at 10 atm, at an equivalence ratio of 1. Kinetic modeling was performed using a reaction mechanism resulting from the merging of validated kinetic schemes for the oxidation of the components of the present mixtures (iso-octane, ethanol, and 1-butanol). Good agreement between the experimental results and the computations was observed under the present conditions. Reaction path analyses and sensitivity analyses were used to interpret the results.