A novel multiscale modeling approach was developed, implemented as basis of a simulation environment and applied to the fluidized bed spray granulation process. The high detailing level of the simulation is based on the process description on different time and length scales which are coupled by interscale communication laws. This allows considering a higher amount of process parameters, compared to the semi-empirical models which are typically used. The developed concept represents the production plant as flow sheet, with its further dynamic simulation on the macroscale. The influence of parameters such as viscosity of the sprayed suspension, nozzle positions, and temperature of the fluidization air on the whole process can be considered on the microscale.