Two CFD models were formulated for the stirred tank reactor and the storage tank, respectively. With use of the elaborated models, for various thermal runaway scenarios, spatial distributions of liquid velocity, temperature, and key reactant concentration were determined as a function of time. Knowledge of temperature nonuniformity inside the reactor and storage tank vessels is particularly crucial for the appropriate location of temperature sensors, which assures a detection of thermal runaway as early as possible. The results obtained indicate that the CFD models can be very useful to elaborate efficient and robust methods for online early warning of runaway.