This paper investigates output-feedback control for a class of stochastic high-order nonlinear systems with time-varying delay for the first time. By introducing the adding a power integrator technique in the stochastic systems and a rescaling transformation, and choosing an appropriate Lyapunov-Krasoviskii functional, an output-feedback controller is constructed to render the closed-loop system globally asymptotically stable in probability and the output can be regulated to the origin almost surely. A simulation example is provided to show the effectiveness of the designed controller. (C) 2011 Elsevier Ltd. All rights reserved.