Glasses/glass-ceramics with nominal composition 34SiO(2)-(45 - x)CaO-16P(2)O(5)-4.5MgO-0.5CaF(2) - xFe(2)O(3) (where x = 10, 15, 20 wt%) have been prepared by melt quenching technique. These are characterized for structural and micro structural properties by using XRD and Raman spectroscopy. Interaction of glass-ceramics samples with bovine serum albumin (BSA) has been studied using SEM and TOF-SIMS. The formation of magnetite, apatite and wollastonite phases are observed. Typical sizes of crystallites as seen from SEM measurement are 30-50 nm. The progressive addition of iron oxide to glass leads to increase in number of non-bridging oxygen, which in turn affects the response of glass-ceramics when immersed in BSA. The samples with 15 and 20 wt% Fe2O3 have shown nearly full surface coverage with BSA, while the sample with 10 wt% Fe2O3 shows poor adhesion. (C) 2011 Elsevier B. V. All rights reserved.