The development of stable skeletal joint prostheses-con-formal, nanoscale electrostatic coatings capable of de novo bone regeneration-is reported by P. T. Hammond and co-workers on page 1445. These coatings contain a combination of hydroxyapatite and bone growth factor, components which are present in and which regulate the structure of the bone. Osteoblast cells adhere to these coatings and lay down new bone on and around the implant for stable bonding with the surrounding bone tissue.