Stimuli-responsive nanofl uidic systems in room temperature ionic liquids ( RTILs). The nanofl uidic device can withstand high temperatures up to 200 degrees C, in which conventional water-based smart materials and nanodevices are invalid. The smart nanopores can be "irreversibly" turned off above the transition temperature of ca. 120-150 degrees C, actuated by the conformational change of the chemicallymodifi ed polymer brushes.