Experiments were performed to investigate the heat transfer characteristics of impingement how of transformer oil and 3M fluorinert liquid FC-72 in two-dimensional micro-channels. Jet impingement technique was used in this research for its high heat transfer rate and large potential in industrial applications. Local heat transfer coefficients were recorded both at stagnation and parallel flow regions in the range of Reynolds number from 70 to 170, and 911 to 4807, for oil and FC-72, respectively. The influences of different parameters, such as liquid velocity, channel size and fluid Prandtl number, on heat transfer behavior were examined. Empirical correlations of local heat transfer were developed for the whole channels. Very significant enhancement of heat transfer was observed and recorded.