This article is concerned with the effects of flow and migration of nanoparticles on heat transfer in a straight channel occupied with a porous medium. Investigation of force convective heat transfer of nanofluids in a porous channel has not been considered completely in the literature and this challenge is generally considered to be an open research topic that may require more study. The fully developed flow and steady Darcy-Brinkman-Forchheimer equation is employed in porous channel. The thermal equilibrium model is assumed between nanofluid and solid phases. It is assumed that the nanoparticles are distributed non-uniformly inside the channel. As a result the volume fraction distribution equation is also coupled with governing equations. The effects of parameters such as Lewis number, Schmidt number, Brownian diffusion, and thermophoresis on the heat transfer are completely studied. The results show that the local Nusselt number is decreased when the Lewis number is increased. It is observed that as the Schmidt number is increased, the wall temperature gradient is decreased and as a consequence the local Nusselt number is decreased. The effects of Lewis number, Schmidt number, and modified diffusivity ratio on the volume fraction distribution are also studied and discussed.