We use molecular dynamics method (MD) combined with multi-particle collision dynamics (MPCD) method to investigate the effects of poiseuille flow on the conformations and migration behaviors of semiflexible chains confined in two infinite flat planes. At low shear rates, the semiflexible chain keeps semirigid conformation in the plane parallel to the infinite flat wall. At high shear rates, the semiflexible chain extends in the flow direction, and it migrates away from the two plat planes with considering hydrodynamic interactions between polymers and solvent molecules. Comparisons with flexible chains are also made, and this study can help us to understand the biological process under confined microfluidic devices. (C) 2012 Elsevier Ltd. All rights reserved.