We report a non-enzymatic glucose sensor that is based on a gold micropillar array electrode and was fabricated by using a combination of photolithographic techniques and electroplating. The electrode exhibits (a) a larger electroactive area, (b) enhanced surface roughness, and (c) enhanced catalytic activity toward the electro-oxidation of glucose. We demonstrate its potential application in sensing glucose with high operational stability, high sensitivity and relatively high selectivity. The response to glucose is linear in the 0.5 to 9 mM concentration range, the sensitivity is 13.2 mu A mM(-1) cm(-2), and the detection limit is 60 mu M. The simplicity of the sensor preparation makes gold micropillar array electrodes a good candidate for easy glucose determinations. (C) 2012 The Electrochemical Society. [DOI: 10.1149/2.018206jes] All rights reserved.