Journal of the American Chemical Society, Vol.133, No.29, 11066-11068, 2011
Nickel-Catalyzed Cycloaddition of o-Arylcarboxybenzonitriles and Alkynes via Cleavage of Two Carbon-Carbon sigma Bonds
An intermolecular cycloaddition reaction has been developed, where o-arylcarboxybenzonitriles react with alkynes to afford coumarins in the presence of Ni(0)/P(CH(2)Ph)(3)/MAD as a catalyst. The reaction process displays an unusual mechanistic feature the cleavage of two independent C-CN and C-CO bonds.