Improvement of Mechanical Properties and Blood Compatibility of PLLA Nanocomposites by Incorporation of Polyhedral Oligomeric Silsesquioxane

Quang Vu Bach; Jiyeon Choi; Yoon Ki Joung; Bang Ju Park; Dong Keun Han

Macromolecular Research, Vol.20, No.9, 996-1001, September, 2012

DOI10.1007/s13233-012-0196-x Export Citation

Improvement of Mechanical Properties and Blood Compatibility of PLLA Nanocomposites by Incorporation of Polyhedral Oligomeric Silsesquioxane

Quang Vu Bach, Jiyeon Choi, Yoon Ki Joung, Bang Ju Park¹, and Dong Keun Han^†

Center for Biomaterials, Korean Institute of Science and Technology, Seoul, 130-650, Korea
¹College of BioNano Tech, Gachon University, Gyeonggi, 461-701, Korea

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A series of hybrid nanocomposites containing poly(L-lactide) (PLLA) and polyhedral oligomeric silsesquioxane (POSS) was prepared by solvent casting method for the enhancement of the mechanical properties of PLLA. One of them was mixed by only a physical blending between PLLA and POSS to form PLLA/POSS nanocomposite that did not show considerable improvement. In the other hand, two types of PLLA-POSS additives were synthesized via the ring-opening polymerization of L-lactide in the presence of POSS in different content. On these additives, POSS played as not only an initiator for the ring-opening polymerization reaction due to its hydroxyl functional groups on the surface but also a type of hybrid filler for PLLA/PLLA-POSS nanocomposite after mixing with PLLA matrix. PLLA/PLLA-POSS composite showed significant improvement in mechanical properties because of covalent bonding between PLLA and POSS. In particular, the tensile modulus has been apparently increased in PLLA/5PLLA-5POSS nanocomposites (1,449 MPa) with respect to PLLA control (498 MPa). SEM and XRD data indicated that the dispersion of PLLA-modified POSS was better than that of POSS in PLLA matrix. Although the contact angle was not significantly different, the protein adsorption and platelet adhesion are reduced slightly in PLLA/PLLA-POSS nanocomposite as compared to those of PLLA control and PLLA/POSS. Therefore, it is expected that biodegradable POSS nanocomposite may be helpful to be utilized in biomedical devices such as drug-eluting stents and artificial implants.

Keywords:PLLA;POSS;nanocomposite;mechanical property;blood compatibility.

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[2] Anderson JM, Shive MS, Adv. Drug Deliv. Rev., 28, 5 (1997)

[3] Lunt J, Polym. Degrad. Stab., 59, 145 (1998)

[4] Uurto I, Kotsar A, Isotalo T, Mikkonen J, Martikainen PM, Kellomaki M, Tormala P, Tammela TL, Talja M, Salenius JP, J. Mater. Sci. Mater. Med., 18, 1543 (2007)

[5] Liu X, Ma PX, Ann. Biomed. Eng., 32, 477 (2004)

[6] Chrissafis K, Pavlidou E, Paraskevopoulos KM, Beslikas T, Nianias N, Bikiaris D, J. Therm. Anal. Calorim., 105, 313 (2011)

[7] Hoidy W, Al-Mulla E, Khalid AJ, J. Polym. Environ., 18, 608 (2010)

[8] Tsuji H, Kawashima Y, Takikawa H, Tanaka S, Polymer, 48(14), 4213 (2007)

[9] Abe Y, Gunji T, Prog. Polym. Sci., 29, 149 (2004)

[10] Romo-Uribe A, Mather PT, Haddad TS, Lichtenhan JD, J. Polym. Sci. B: Polym. Phys., 36(11), 1857 (1998)

[11] Li G, Wang L, Ni H, Pittman CU, J. Inorg. Organomet.Polym., 11, 123 (2001)

[12] Goffin AL, Duquesne E, Raquez JM, Miltner H, Ke X, Alexandre M, Van Tendeloo G, Van Mele B, Dubois P, J. Mater. Chem., 20, 9415 (2010)

[13] Matejka L, Strachota A, Plestil J, Whelan P, Steinhart M, Slouf M, Macromolecules, 37(25), 9449 (2004)

[14] Wu FM, Xie TX, Yang GS, J. Polym. Sci. B: Polym. Phys., 48(16), 1853 (2010)

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