Polymeric Tube-Shaped Devices with Controlled Geometry for Programmed Drug Delivery

Min Park; Chun Gwon Park; Seung Ho Lee; Ji Eun Lee; Eunbit Cho; Mark R. Prausnitz; Young Bin Choy

Macromolecular Research, Vol.20, No.9, 960-967, September, 2012

DOI10.1007/s13233-012-0140-0 Export Citation

Polymeric Tube-Shaped Devices with Controlled Geometry for Programmed Drug Delivery

Min Park¹, Chun Gwon Park¹, Seung Ho Lee¹, Ji Eun Lee¹, Eunbit Cho², Mark R. Prausnitz³, and Young Bin Choy^{1, 2, †}

¹Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul, 152-742, Korea
²Department of Biomedical Engineering, College of Medicine, Seoul National University, Seoul, 110-799, Korea
³School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0100, USA

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We developed a modular tube-shaped device as a proof of principle to enable the programmed release of encapsulated molecules for controlled drug delivery. Each drug-delivery tube module was prepared by assembling two separate silicone tubes in a series, one filled with a model compound (sodium fluorescein) and the other with a diffusional barrier material (polyethylene oxide, PEO). We varied the length of the PEO-filled tubes to control the release from the drug-delivery tube devices. The onset times and periods of drug release increased with the length of the PEO tube. To program the drug release, therefore, we prepared devices with combinations of drug-delivery tube modules with different lengths of PEO-filled tubes. Using PEO-filled tubes with very different lengths achieved a pulsatile drug release while a continuous drug release was realized by using PEO-filled tubes with small differences in length. We concluded that the modular combination of drug-delivery tubes, each composed of a diffusionbarrier tube of different length, demonstrates good potential for applications in programmed drug delivery.

Keywords:continuous drug release;drug-delivery tube;polyethylene oxide (PEO);programmed drug delivery;pulsatile drug;silicone.

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[1] Orive G, Hernandez R, Gascon A, Dominguez-Gil A, Pedraz J, Curr. Opin. Biotechnol., 14, 659 (2003)

[2] Reddy P, Swarnalatha D, Int. J. PharmTech Res., 2, 2025 (2010)

[3] Kim S, Kim J, Jeon O, Kwon I, Park K, Eur. J. Pharm.Biopharm., 71, 420 (2009)

[4] Hickey Y, Kreutzer D, Burgess D, Moussy F, Biomaterials., 23, 1649 (2002)

[5] Reddy J, Jyothsna M, Saleem T, Chetty C, J. Pharm.Sci. Res., 1, 4 (2009)

[6] Stubbe B, De Smedt S, Demeester J, Pharm. Res., 21, 1732 (2004)

[7] De Geest B, Mehuys E, Laekeman G, Demeester J, De Smedt S, Expert Opin. Drug Deliv., 3, 459 (2006)

[8] Varde N, Pack D, Expert Opin. Biol. Ther., 4, 35 (2004)

[9] Allison S, Expert Opin. Drug Deliv., 5, 615 (2008)

[10] Yeo Y, Park K, Arch. Pharm. Res., 27, 1 (2004)

[11] Huang X, Brazel C, J. Control. Release., 73, 121 (2001)

[12] Staples M, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2, 400 (2010)

[13] Prescott J, Lipka S, Baldwin S, Sheppard N, Maloney J, Coppeta J, Yomtov B, Staples M, Santini J, Nat. Biotechnol., 24, 437 (2006)

[14] Hilt J, Peppas N, Int. J. Pharm., 306, 15 (2005)

[15] Staples M, Daniel K, Cima M, Langer R, Pharm. Res., 23, 847 (2006)

[16] Santini J, Richards A, Scheidt R,Cima M, Langer R, Angew. Chem. Int. Ed., 39, 2396 (2000)

[17] Ziaie B, Baldi A, Lei M, Gu Y, Siegel R, Adv. Drug Deliv. Rev., 56, 145 (2004)

[18] Croxatto HB, Ann. Med., 25, 155 (1993)

[19] Rastogi A, Luo Z, Wu Z, Ho PS, Bowman PD, Stavchansky S, Biomed. Microdevices., 12, 5 (2010)

[20] Lee H, Cima M, J. Control. Release., 2, 133 (2010)

[21] Quinn KJ, Courtney JM, Brit. Polym. J., 20, 1 (1988)

[22] Habal M, Arch Surg., 119, 7 (1984)

[23] Charvat J, Linke Z, Horaekova M, Prausova J, Support Care Cancer., 14, 1162 (2006)

[24] Santos P, Oper. Tech. Otolaryngol. Head Neck Surg., 15, 201 (2004)

[25] Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999)

[26] Webster R, Elliott V, Park BK, Walker D, Hankin M, Taupin P, PEGylated Protein Drugs: Basic Science and Clinical Applications, University of Padova Press, Padova (2009)

[27] Croxatto HB, Ann. Med., 25, 2 (1993)

[28] Saltzman WM, Drug Delivery: Engineering Principles for Drug Therapy, Oxford University Press, New York (2001)

[29] Shi Y, Li L, Expert Opin. Drug Deliv., 2, 1039 (2005)

[30] Putney S, Burke P, Nat. Biotechnol., 16, 153 (1998)

[31] Liu X, Pettway G, McCauley L, Ma P, Biomaterials., 28, 4124 (2007)

[32] Edlund U, Albertsson A, Adv. Polym. Sci., 157, 2000 (2002)

[33] Yasukawa T, Ogura Y, Sakurai E, Tabata Y, Kimura H, Adv. Drug Deliv. Rev., 57, 2033 (2005)

[34] Menei P, Montero-Menei C, Venier M, Benoit J, Expert Opin. Drug Deliv., 2, 363 (2005)