Carbohydrate polymer grafting on stainless steel surface and its biocompatibility study

Chan-Koo Kang; Yoon-Sik Lee

Journal of Industrial and Engineering Chemistry, Vol.18, No.5, 1670-1675, September, 2012

DOI10.1016/j.jiec.2012.03.007 Export Citation

Carbohydrate polymer grafting on stainless steel surface and its biocompatibility study

Chan-Koo Kang^{1, 2}, and Yoon-Sik Lee^{3, 4, †}

¹Organic Synthesis Laboratory, School of Chemical and biological Engineering, Interdisciplinary Program of Bioengineering, Seoul National University, Seoul 151-747, Republic of Korea
²Industry & Strategy Department, Samsung Economical Research Institute, Seoul 137-955, Republic of Korea
³Organic Synthesis Laboratory, School of Chemical and biological Engineering, Seoul National University, Seoul 151-747, Republic of Korea
⁴Interdisciplinary Program of Bioengineering, Seoul National University, Seoul 151-747, Republic of Korea

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Surface science plays a critical role in biomaterials development as most biological reactions occur at their surfaces. The suitable choice of coating material, the surface structure and its biocompatibility are essential for fabricating a biomaterial. Herein, we have developed a biocompatible surface modification technology composed of surface electropolishing and carbohydrate polymer grafting, which can be applied to stainless steel, the most widely used stent. The surface of the stainless steel was sequentially modified by acid-treatment, silanization, and covalent attachment of chitosan and dextran. The extensive surface analysis confirmed that the surface was changed from hydrophobic to hydrophilic and from rough to smooth. The biological experiments revealed that the surface-modified stainless steel not only inhibited non-specific fibrinogen adsorption but also repelled most of proteins from human blood, when compared to bare stainless steel. It was demonstrated that our simple approach for surface modification could efficiently improve the biocompatibility of a stainless steel-based medical device.

Keywords:Surface modification;Stainless steel;Chitosan;Dextran;Biocompatibility

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Kang CK, Lee YS, J. Mater. Sci. Mater. Med., 18(7), 1389 (2007)
Hoven VP, Tangpasuthadol V, Angkitpaiboon Y, Vallapa N, Kiatkamjornwong S, Carbohydr. Polym., 68(1), 44 (2007)
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Yu DG, Jou CH, Lin XC, Yang MC, Colloids Surf. B., 54(2), 222 (2007)
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[Related Articles]

[1] Castner DG, Ratner BD, Surf. Sci., 500(1-3), 28 (2002)

[2] Ha CS, Gardella JA, Chem. Rev., 105(11), 4205 (2005)

[3] Tirrell M, Kokkoli E, Biesalski M, Surf. Sci., 500(1-3), 61 (2002)

[4] Oehr C, Nucl. Instrum. Meth. B., 208, 40 (2003)

[5] Luscher TF, Steffel J, Eberli FR, Joner M, Nakazawa G, Tanner FC, Virmani R, Circulation., 115, 1051 (2007)

[6] Garg S, Serruys PW, J. Am. Coll. Cardiol., 56(10), S1-S42 (2010)

[7] Courtney JM, Lamba NMK, Sundaram S, Forbes CD, Biomaterials., 15(10), 737 (1994)

[8] Pitt WG, Park K, Cooper SL, J. Colloid Interface Sci., 111, 343 (1986)

[9] Griffith LG, Acta Mater., 48(1), 263 (2000)

[10] Charles PT, Stubbs VR, Soto CM, Martin BD, White BJ, Taitt CR, Sensors(Basel)., 9(1), 645 (2009)

[11] Ikada Y, Biomaterials., 15(10), 725 (1994)

[12] Helsen JA, Breme HJ, Metals as Biomaterials, Wiley, New York (1998)

[13] Tsuruta T, Hayashi T, Kataoka K, Ishihara K, Kimura Y, Biomedical Applications of Polymeric Materials, CRC Press, Boca Raton (1993)

[14] Tang CJ, Wang GX, Wu X, Li ZG, Shen Y, Lee JCM, Yu QS, J. Vasc. Surg., 53(2), 461 (2011)

[15] Shaulov Y, Okner R, Levi Y, Tal N, Gutkin V, Mandler D, Domb AJ, ACS Appl.Mater. Int., 1(11), 2519 (2009)

[16] Martz EO, Goel VK, Pope MH, Park JB, J. Biomed. Mater. Res., 38(3), 267 (1997)

[17] Thierry B, Merhi Y, Bilodeau L, Trepanier C, Tabrizian M, Biomaterials., 23(14), 2997 (2002)

[18] Lewis AL, Tolhurst LA, Stratford PW, Biomaterials., 23(7), 1697 (2002)

[19] Caro A, Humblot V, Methivier C, Minier M, Salmain M, Pradier CM, J. Phys. Chem. B, 113(7), 2101 (2009)

[20] Chaudhari S, Sainkar SR, Patil PP, Prog. Org. Coat., 58(1), 54 (2007)

[21] Kang CK, Lee YS, J. Mater. Sci. Mater. Med., 18(7), 1389 (2007)

[22] Hoven VP, Tangpasuthadol V, Angkitpaiboon Y, Vallapa N, Kiatkamjornwong S, Carbohydr. Polym., 68(1), 44 (2007)

[23] Ye P, Jiang J, Xu ZK, Colloids Surf. B., 60(1), 62 (2007)

[24] Yu DG, Jou CH, Lin XC, Yang MC, Colloids Surf. B., 54(2), 222 (2007)

[25] Eriksson M, Notley SM, Pelton R, Wagberg L, J. Colloid Interface Sci., 310(1), 312 (2007)

[26] Wang AJ, Xu JJ, Chen HY, J. Chromatogr. A., 1147(1), 120 (2007)

[27] Tao YY, Carta G, J. Chromatogr. A., 1211(1-2), 70 (2008)

[28] Eidelman RS, Hennekens CH, Eur. Heart J., 24(6), 499 (2003)