This paper presents a generalized formulation of simplified decoupling to n x n processes that allows for different configurations depending on the decoupler elements set to unity. To apply this decoupiing method, the realizability conditions are stated. Then, from the previous decoupling in combination with a decentralized control, the formulation of a centralized control by simplified decoupling is developed. After reducing the controller, this last proposed method is modified to a multivariable PID control. From an implementation point of view, the windup problem is addressed for these methods, and an anti-windup scheme for multivariable PID controllers is proposed. Comparisons with other works demonstrate the effectiveness of these methodologies, through the use of several simulation examples and an experimental lab process. (C) 2012 Elsevier Ltd. All rights reserved.