This paper presents methods for suppressing the slugging phenomenon occurring in multiphase flow. The considered systems include industrial oil production facilities such as gas-lifted wells and flowline risers with low-points. Given the difficulty to maintain sensors in deep locations, a particular emphasis is put on observer-based control design. It appears that, without any upstream pressure sensor, such a strategy can stabilize the flow. Besides, given a measurement or estimate of the upstream pressure, we propose a control strategy alternative to the classical techniques. The efficiency of these methods is assessed through experiments on a mid-scaled multiphase flow loop. (C) 2012 Elsevier Ltd. All rights reserved.