Preparation of Furfuryl-Fish Gelatin (F-f.gel) Cured Using Visible-Light and Its Application as an Anti-Adhesion Agent

Shin-Hye Park; Si-Yoong Seo; Hyung-Jae Lee; Ha-Na Na; Jea-Woo Lee; Hee-Dong Woo; Tae-Il Son

Macromolecular Research, Vol.20, No.8, 842-846, August, 2012

DOI10.1007/s13233-012-0128-9 Export Citation

Preparation of Furfuryl-Fish Gelatin (F-f.gel) Cured Using Visible-Light and Its Application as an Anti-Adhesion Agent

Shin-Hye Park, Si-Yoong Seo, Hyung-Jae Lee, Ha-Na Na, Jea-Woo Lee, Hee-Dong Woo, and Tae-Il Son^†

Department of Biotechnology and Bio-Environmental Technology (BET) Research Institute, Chung-Ang University, Gyeonggi, 456-756, Korea

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Adhesions occurring on a variety tissues and operation sites are a serious side effect of surgery and may require additional surgery for removal. Therefore, Furfuryl-fish gelatin (F-f.gel) was synthesized by introducing a furan ring to fish gelatin for application as an anti-adhesion agent. F-f.gel was cured by visible-light irradiation, which changed the material from a solution to a film. The prepared F-f.gel was characterized by proton nuclear magnetic resonance spectroscopy (1H NMR), substitution ratio, gel permeation chromatography (GPC), methyl thiazolyl tetrazolium (MTT) assay, and tests for measuring photo immobilization, water contact angle (WCA), and cell attachment. The results showed that F-f.gel was effective as an anti-adhesion agent.

Keywords:fish gelatin;anti-adhesion agent;photo curing;furfuryl group;gelatin film.

[References]

Karim AA, Bhat R, Food Hydrocoll., 23, 563 (2009)
Tabata Y, Ikada Y, Adv. Drug Deliv. Rev., 31, 287 (1998)
Boanini E, Rubini K, Panzavolta S, Bigi A, Acta Biomater., 6, 383 (2010)
Yang LJ, Ou YC, Royal Soc. Chem., 5, 979 (2005)
Radmacher M, Fritz M, Hansma PK, Biophys. J., 69, 264 (1995)
Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS, Biomaterials., 20, 409 (1999)
Liu WG, De Yao K, Wang GC, Li HX, Polymer, 41(20), 7589 (2000)
Cosgrove T, White SJ, Zarbakhsh A, Heenan RK, Howe AM, Langmuir, 11(3), 744 (1995)
Jongjareonrak A, Benjakul S, Visessanguan W, Prodpran T, Tanaka M, Food Hydrocoll., 20, 492 (2006)
Sarabia AI, Gomez-Guillen MC, Montero P, Food Chem., 70, 71 (2000)
Choi SS, Regenstein JM, J. Food Sci., 65, 194 (2000)
Bower CK, Avena-Bustillos RJ, Olsen CW, McHugh TH, Bechtel RJ, J. Food Sci., 71, 141 (2006)
Avena-Bustiollos RJ, Olsen CW, Olson DA, Chiou B, Yee E, Bechtel PJ, McHugh TH, J. Food Sci., 71, 202 (2006)
Badii F, Howell NK, Food Hydrocoll., 20, 630 (2006)
Chiou BS, Avena-Bustillos RJ, Shey J, Yee E, Bechtel PJ, Imam SH, Glenn GM, Orts WJ, Polymer, 47(18), 6379 (2006)
Ponsonby AL, McMichael A, van der Mei I, Toxicology., 181, 71 (2002)
Son TI, Sakuragi M, Takahashi S, Takahashi S, Obuse S, Kang J, Fujishiro M, Matsushita H, Gong J, Shimizu S, Tajima Y, Yoshida Y, Suzuki K, Yamamoto T, Nakamura M, Ito Y, Acta Biomater., 6, 4005 (2010)
Park S, Seo S, Na H, Kim K, Lee J, Woo H, Lee J, Seok H, Lee J, Chung S, Chung KH, Han DK, Ito Y, Jang E, Son T, Macromol. Res., 19(9), 921 (2011)

[Referenced By]

[1] Karim AA, Bhat R, Food Hydrocoll., 23, 563 (2009)

[2] Tabata Y, Ikada Y, Adv. Drug Deliv. Rev., 31, 287 (1998)

[3] Boanini E, Rubini K, Panzavolta S, Bigi A, Acta Biomater., 6, 383 (2010)

[4] Yang LJ, Ou YC, Royal Soc. Chem., 5, 979 (2005)

[5] Radmacher M, Fritz M, Hansma PK, Biophys. J., 69, 264 (1995)

[6] Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS, Biomaterials., 20, 409 (1999)

[7] Liu WG, De Yao K, Wang GC, Li HX, Polymer, 41(20), 7589 (2000)

[8] Cosgrove T, White SJ, Zarbakhsh A, Heenan RK, Howe AM, Langmuir, 11(3), 744 (1995)

[9] Jongjareonrak A, Benjakul S, Visessanguan W, Prodpran T, Tanaka M, Food Hydrocoll., 20, 492 (2006)

[10] Sarabia AI, Gomez-Guillen MC, Montero P, Food Chem., 70, 71 (2000)

[11] Choi SS, Regenstein JM, J. Food Sci., 65, 194 (2000)

[12] Bower CK, Avena-Bustillos RJ, Olsen CW, McHugh TH, Bechtel RJ, J. Food Sci., 71, 141 (2006)

[13] Avena-Bustiollos RJ, Olsen CW, Olson DA, Chiou B, Yee E, Bechtel PJ, McHugh TH, J. Food Sci., 71, 202 (2006)

[14] Badii F, Howell NK, Food Hydrocoll., 20, 630 (2006)

[15] Chiou BS, Avena-Bustillos RJ, Shey J, Yee E, Bechtel PJ, Imam SH, Glenn GM, Orts WJ, Polymer, 47(18), 6379 (2006)

[16] Ponsonby AL, McMichael A, van der Mei I, Toxicology., 181, 71 (2002)

[17] Son TI, Sakuragi M, Takahashi S, Takahashi S, Obuse S, Kang J, Fujishiro M, Matsushita H, Gong J, Shimizu S, Tajima Y, Yoshida Y, Suzuki K, Yamamoto T, Nakamura M, Ito Y, Acta Biomater., 6, 4005 (2010)

[18] Park S, Seo S, Na H, Kim K, Lee J, Woo H, Lee J, Seok H, Lee J, Chung S, Chung KH, Han DK, Ito Y, Jang E, Son T, Macromol. Res., 19(9), 921 (2011)