Forward osmosis (FO) technology has become increasingly attractive in the past decades for water related applications and will likely continue to develop rapidly in the future. This calls for the development of high performance FO membranes. Thin film composite (TFC) polyamide FO membranes with tailored support structure were prepared in the current study. The porous polysulfone substrates with finger-like pore structures were prepared via phase inversion, and the polyamide rejection layers were synthesized by interfacial polymerization. The resulting TFC FO membranes had small structural parameters (s = 0.67-0.71 mm) due to the thin cross-section, low tortuosity, and high porosity of the membrane substrates. Meanwhile, their rejection layers exhibited superior separation properties (higher water permeability and better selectivity) over commercial FO membranes. When the rejection layer is oriented towards the draw solution, FO water flux as high as 54 L/m(2) h can be achieved with a 2 M NaCl draw solution while maintaining relatively low solute reverse diffusion. Comparison of the synthesized TFC FO membranes with commercial FO and RO membranes reveals the critical importance of the substrate structure, with straight finger-like pore structure preferred over spongy pore structure to minimize internal concentration polarization. In addition, membranes with high water permeability and excellent selectivity are preferred to achieve both high FO water flux and low solute flux. (C) 2011 Elsevier B.V. All rights reserved.