In the present investigation, leaf and stem bark of Crataeva magna are evaluated for their antioxidant activity and inhibition of key enzymes relevant to hyperglycemia. Both the parts exhibited significant antioxidant and anti-a-glucosidase activity. The results will lead in favor of the use of this plant as a potential additive/nutraceutical antioxidant compound. (C) 2011, The Society for Biotechnology, Japan. All rights reserved.