Journal of Bioscience and Bioengineering, Vol.113, No.1, 26-29, 2012
Display of the antigenic region of Nipah virus nucleocapsid protein on hepatitis B virus capsid
The C-terminal domain of Nipah virus (NiV) nucleocapsid protein (NP401-532) was inserted at the N-terminus and the immunodominant loop of hepatitis B core antigen (HBc). The stability of NP401-532 increased tremendously when displayed on the HBc particles. These particles reacted specifically with the swine anti-NiV and the human anti-HBc antisera. (C) 2011, The Society for Biotechnology, Japan. All rights reserved.
Keywords:Nipah virus;Nucleocapsid protein;Hepatitis B virus;Hepatitis B core antigen;Virus-like particles