Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level

Marui J; Yamane N; Ohashi-Kunihiro S; Ando T; Terabayashi Y; Sano M; Ohashi S; Ohshima E; Tachibana K; Higa Y; Nishimura M; Koike H; Machida M

Journal of Bioscience and Bioengineering, Vol.112, No.1, 40-43, 2011

DOI10.1016/j.jbiosc.2011.03.010 Export Citation

Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level

Marui J, Yamane N, Ohashi-Kunihiro S, Ando T, Terabayashi Y, Sano M, Ohashi S, Ohshima E, Tachibana K, Higa Y, Nishimura M, Koike H, Machida M

A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of Kit. (C) 2011, The Society for Biotechnology, Japan. All rights reserved.

Keywords:Aspergillus oryzae;Kojic acid;Secondary metabolism;Transcriptional regulation;Zn(II)(2)Cys(6) transcription factor