The effect of type of inlet conditions on the predictions of Eulerian-Eulerian simulations of a circulating fluidized bed riser has been investigated in both 2D and 3D domains. The 2D simulations were conducted using 3 different inlet configurations: (A) solids entering in radial direction from a two-sided inlet and gas entering axially from the bottom inlet, (B) solid entering axially from a two-sided bottom inlet near the wall and gas entering axially from a bottom inlet at the center, and (C) gas phase entering axially from a two-sided bottom inlet near the wall and solids entering axially from a bottom inlet at the center. In 2D simulations, it was found that both time-averaged axial velocity and solids volume fraction radial profiles were functions of the inlet kinetic energy as well as gas-solid mixing patterns at the inlet. Whereas 2D simulations using boundary conditions A and C showed significant deviations from experimental profiles, the boundary condition B as well as full-scale 3D simulations gave reasonable agreements with experimental observations.