The solubilities of decahydropyrazino [2,3-b]pyrazine (DHPP) in methanol, ethanol, and 2-propanol were measured at temperatures ranging from 274.95 to 354.75 K The last crystal disappearance method was used to determine the solubility of DHPP. The experimental data were correlated by the van't Hoff plot, lambda h (Buchowski) equation, modified Apelblat equation, and two local composition models (Wilson and NRTL). Moreover, the densities of (DHPP + water) solution were measured from 274.25 to 355.95 K, and the liquid molar volume of DHPP, V-m1(T), was obtained and used to calculate the parameters in the Wilson model. It was found that NRTL model gave the best correlation results. On the basis of the NRTL model and experimental data, the thermodynamic excess functions (Delta G(E), Delta S-E, and Delta H-E) of DHPP + alcohols (methanol, ethanol, and 2-propanol) systems were determined. Furthermore, the infinite-dilution activity coefficient and the infinite-dilution reduced excess enthalpy (gamma(infinity)(1) and Delta H-E1(infinity)) were derived.