Molecular dynamics (MD) simulations were performed to determine the self-diffusivity (D-i,D-self) and the Maxwell-Stefan diffusivity (D-i) of hydrogen, argon, carbon dioxide, methane, ethane, propane, n-butane, n-pentane, and n-hexane in BTP-COF, which is a covalent organic framework (COF) that has one-dimensional 3.4-nm-sized channels. The MD simulations show that the zero-loading diffusivity (D-i(0)) is consistently lower, by up to a factor of 10, than the Knudsen diffusivity (D-i,D-Kn) values. The ratio D-i(0)/D-i,D-Kn is found to correlate with the isosteric heat of adsorption, which, in turn, is a reflection of the binding energy for adsorption on the pore walls: the stronger the binding energy, the lower the ratio D-i(0)/D-i,D-Kn. The diffusion selectivity, which is defined by the ratio D-1,D-self D-2,D-self for binary mixtures, was determined to be significantly different from the Knudsen selectivity (M-2/M-1)(1/2), where M-i is the molar mass of species i. For mixtures in which component 2 is more strongly adsorbed than component 1, the expression (D-1,D-self/D-2,D-self)/(M-2/M-1)(1/2) has values in the range of 1-10; the departures from the Knudsen selectivity increased with increasing differences in adsorption strengths of the constituent species. The results of this study have implications in the modeling of diffusion within mesoporous structures, such as MCM-41 and SBA-15.