Using appropriate nonaqueous solvents to replace water as reaction medium in chemical industries has gained more and more attention recently. Many of them have the special ability to dissolve some compounds and thus may make the reaction more stable in comparison with a water-containing environment. Dimethyl sulfoxide (DMSO) is probably the most frequently mentioned aprotic nonaqueous solvent with extensive applications because of its high stability and powerful solubility. In this study, the solubilities of four inorganic salts, namely potassium nitrate (KNO3), potassium chloride (KCl), potassium bromide (KBr) and sodium chloride (NaCl), in DMSO are measured in the temperature range of 302 through 354 K using a dynamic method. The solubility order of the salts in DMSO is experimentally determined as KNO3 > KBr > NaCl > KCl. The molality solubilities show linear dependencies on temperature and the temperature effect on the solubility for the salts follows the same order as the solubility result. The solubility products of the salts in DMSO at different temperatures are obtained by estimating the solubility products in water and the Gibbs energy of transfer from water to DMSO. Then electrolyte models of the Wilson, NRTL, and UNIQUAC equations are used to model the solubility of the inorganic salts in DMSO. It is found that the three-parameter E-Wilson equation gives the best correlation results followed by the Pitzer, E-NRTL, and E-UNIQUAC equations, while the two-parameter E-Wilson equation presents the worst results in terms of the overall standard deviation.