The solubility of Deflazacort in four solvents, acetone, ethyl acetate, ethanol and 2-propanol, was measured at temperatures ranging from 293.15K to 348.15K at atmospheric pressure using Laser Monitoring Technique. The solubility data were correlated by the modified Apelblat model. Then the dissolution enthalpy and entropy of Deflazacort were predicted from the solubility data using van't Hoff equation. In this study, it should be concluded that the viscosity and surface tension of solvents affect the solubility behavior, dissolution enthalpy and entropy of Deflazacort in different solvents. (C) 2011 Elsevier B.V. All rights reserved.