Inorganic Chemistry, Vol.38, No.3, 422-423, 1999
Modeling the catalytic cycle of liver alcohol dehydrogenase: Synthesis and structural characterization of a four-coordinate zinc ethoxide complex and determination of relative Zn-OR versus Zn-OH bond energies
Relative Zn-OR (R = H, Me, Et, Bu-t) heterolytic bond energies, of relevance to the catalytic cycle of liver alcohol dehydrogenase (LADH), have been determined by studying a series of alkoxide exchange equilibria. The alkoxides [Tp(But,Me)]ZnOR also undergo "hydride" transfer reactions which are related to the mechanism of action of LADH.