Granulation is an effectual method to deal with huge amounts of deoiled asphalt (DOA) produced in the residue selective asphaltene extraction (SELEX-Asp) process, and the softening point of DOA plays an important role in asphalt particle production. In this paper, the variation of the softening point under different operation conditions and its influence on asphalt granulation behavior were studied with various solvents and feedstocks. Moreover, properties and structures of five C7 asphaltenes were analyzed with C-13 nuclear magnetic resonance (NMR) and X-ray diffraction (XRD) measurements to examine the reasons of asphalt softening point differences for various residues under the same operation conditions. Ordered degree index (01) and softening point index (SI) were proposed to investigate the influence of asphalt ordered aromatic sheets on the softening point. High softening point asphalt could be obtained with lower temperatures and higher pressures of the extractor, a larger mass ratio of solvent to feed, and a heavier solvent. Asphalt tends to form particles with the increase of the softening point, and nice particles would be produced when the softening point is higher than 170 degrees C. OI of C7 asphaltene is an important factor affecting the asphalt softening point. A close correlation between SI and the softening point was established; that is, feedstocks with a high SI would have the ability to produce high softening point asphalt and possess a good asphalt granulation behavior. The quantity of ordered aromatic sheets in asphalt is the fundamental determinant of the softening point.