This study discusses the development of a generalized geometric population balance model for simulating the growth of asphaltene aggregates from the nanometer scale to micrometer-sized particles. The Smoluchowski kernel has been incorporated to describe the aggregation of asphaltene nanoaggregates, which is induced by the addition of a precipitant, e.g., heptane. Rather than using the discretization of particle sizes based on the particle volumes, a discretization scheme based on the number of asphaltene molecules is incorporated, which ensures that the mass is conserved in this model. The model is in good agreement with the experimental data for the evolution of asphaltene aggregates at different times collected by centrifugation. The particle size distribution (PSD) of the asphaltene aggregates as a function of time is also determined. It was observed that the shift of the PSD to larger diameters is faster in the case of higher heptane concentrations because of the greater mass of asphaltenes precipitated and the higher driving force for their aggregation at these conditions. Additionally, predictions for the onset time for asphaltene precipitation at lower heptane concentrations are also presented.