This paper describes the comparative advantages of using isobutanol as a fuel for SI (spark ignition) engines instead of ethanol. An experimental study of fuel conversion efficiency was performed on a port injection engine fueled with mixtures containing 10, 30 and 50% isobutanol blended with gasoline. Efficiency as well as performance levels were maintained within acceptable limits for all three types of fuel blends compared to running the engine on straight gasoline. These results show that isobutanol is an attractive drop-in fuel for SI engines, and can be blended with gasoline in much higher concentrations compared to ethanol, without any modifications to the fuel system or other engine components. (C) 2011 Elsevier Ltd. All rights reserved.