Chemistry Letters, Vol.40, No.7, 728-729, 2011
Novel Synthetic Azaacridine Analogues as Topoisomerase 1 Inhibitors
Novel azaacridine analogues were synthesized and their antiproliferative activities against K562 and HepG-2 cell lines were evaluated, among which compound 5a was found to display good cytotoxicity. UV-visible spectral absorbance measurements showed that 5a can bind with calf thymus DNA (ct DNA). A relaxation assay indicated that 5a inhibits topoisomerase 1 activity.