A rotating-pulsed fluidized bed (RPFB) dryer was employed to conduct the drying of polyhydroxybutyrate (PHB) cohesive granules. Along the experiments, it was possible to identify, visually, 3 different dynamic regimes that were related with the temperature profile, the drying kinetics and the fluid dynamic behavior. The drying kinetics of PHB showed a short constant drying rate period followed by a decreasing drying rate period. The constant drying rate (N-c) and final moisture content (dry basis) were related to the rotation frequency (responsible for the pulsation effect), temperature and velocity of the inlet air. Furthermore, measurements of molecular mass (gel permeation chromatography analysis) and Carr Index (flowability test) on PHB samples were done before and after the drying. The RPFB dryer showed to be appropriate to dry the PHB granules, resulting in an excellent fluid dynamic behavior that provided uniform drying of the solid. The best conditions of drying were identified at 7 Hz of rotation frequency, 90 degrees C and 0.55 m/s of inlet air temperature and velocity. At these conditions the dried PHB reached final moisture content of 0.56% (wet basis) after 2 h of drying. (C) 2011 Elsevier B.V. All rights reserved.