Catalysis Letters, Vol.141, No.10, 1511-1520, 2011
HClO4-SiO2: An Efficient Reusable Catalyst for the Synthesis of 3,4,5-Trisubstituted 1,2,4-Triazoles Under Solvent-Free Conditions
A series of 3,4,5-trisubstituted 1,2,4-triazoles have been synthesized from N (3)-substituted amidrazones and anhydrides using HClO4-SiO2 at 80 A degrees C under solvent-free conditions. The products were obtained in excellent yields within 5-10 min. Therefore, the present method will be of wide application in organic chemistry and medicinal chemistry.