In this article, a glass nozzle driven by piezoceramics is used to experimentally study the continuous generation of a stream of monodisperse droplets from the breakup of a liquid jet. The approach is demonstrated by examining the breakup dynamics of three distinct liquids. The droplet formation process has been found to be highly controllable and reproducible. The dependence of nozzle performance on liquid properties, flow rate, and disturbance frequency has been investigated. The ratio between the actual disturbance frequency and Reynolds number, omega, is employed at first to represent the operating range that facilitates monodisperse droplet formation. Then, the dimensionless quantity omega*, obtained by multiplying omega by the viscous characteristic time, r(j)(2)/(mu/rho), has been shown to collapse the data for the lower and higher bounds of the actual disturbance frequency ranges that secure monodispersity of the droplets of all the samples tested. The impacts of liquid flow rate and disturbance frequency on the monodisperse droplet size and spacing between two neighboring droplets have been investigated and discussed. (C) 2010 American Institute of Chemical Engineers AIChE J, 57: 1386-1392, 2011