For the first time, the integration of a smart homopolymer poly[2(dimethylamino) ethyl methacrylate] (PDMAEMA), which undergoes both pH- and temperature-induced conformational transitions, is demonstrated in a single glass conical nanopore channel, to achieve a smart nanodevice that can be reversibly switched between the high conducting "on" state and low conducting "off " state with high gating efficiency due to the conformational changes of the homopolymer brush effected by varying the pH and temperature of the surrounding media.