Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization

Young Min Shin; Hansoo Park; Heungsoo Shin

Macromolecular Research, Vol.19, No.8, 835-842, August, 2011

DOI10.1007/s13233-011-0815-y Export Citation

Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization

Young Min Shin¹, Hansoo Park^{2, †}, and Heungsoo Shin^{1, 3, †}

¹Department of Bioengineering, Hanyang University, Seoul, 133-791, Korea
²Department of Biomedical engineering, Chung-ang University, Seoul, 156-756, Korea
³Institute for Bioengineering and Biopharmaceutical Research, Hanyang University, Seoul, 133-791, Korea

E-mail:,

A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-ε-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequently immobilize gelatin (GD-PLCL). The D-PLCL matrices showed minimal changes in the mechanical properties with a tensile strain of 251.0±33.4% and 247.8±32.1% before and after the coating process, respectively. The cellular activities on the fibrous matrices increased in the order of PLCL

Keywords:surface modification;polydopamine;electrospinning;gelatin.

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[10] Leor J, Aboulafia-Etzion S, Dar A, Shapiro L, Barbash IM, Battler A, Granot Y, Cohen S, Circulation, 102, III56 (2000)

[11] Leor J, Cohen S, Ann. N. Y. Acad. Sci., 1015, 312 (2004)

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